Warfarin is an oral anticoagulant, which is commonly used in the treatment and prophylaxis of thromboembolic conditions.Bleeding is the primary adverse effect associated with warfarin.The majority of warfarin-related bleedings are spontaneous minor hemorrhages occurring in the subcutaneous or intramuscular tissues and can be treated by decreasing t
Cortical-striatal synaptic dysfunction, including enhanced toxic signaling by extrasynaptic N-methyl-d-aspartate receptors (eNMDARs), precedes neurodegeneration in Huntington disease (HD).A previous study showed Activin A, whose transcription is upregulated by calcium influx via synaptic Barstools NMDARs, suppresses eNMDAR signaling.Therefore, we e
Eukaryotic cells store neutral lipids such as triacylglycerol (TAG) in lipid droplets (LDs).Here, we have addressed how LDs are functionally linked to the endoplasmic reticulum (ER).We show that, in S.cerevisiae, LD growth is sustained by LD-localized enzymes.When LDs grow in early stationary phase, the diacylglycerol acyl-transferase Dga1p moves f